ENHANCING FUROSEMIDE SOLUBILITY THROUGH COSOLVENT SYSTEMS: A PHARMACEUTICAL APPROACH

Abstract

Drug solubility plays a decisive role in determining the absorption, bioavailability, and overall therapeutic success of pharmaceutical compounds. Furosemide, a widely prescribed diuretic, suffers from poor water solubility, which limits its clinical effectiveness. This study investigates the use of co-solvent systems as a strategy to improve the solubility of furosemide. Various solubility enhancement techniques were reviewed, including particle size reduction, solid dispersion, salt formation, pH adjustment, hydrotropy, cocrystal engineering, and the development of amorphous forms. Particular emphasis was placed on co-solvent systems, where a combination of solvents can significantly increase the drug’s solubility without altering its pharmacological properties. The findings underscore the potential of co-solvent approaches in overcoming solubility-related challenges and improving drug bioavailability. By enhancing solubility, such strategies can ultimately contribute to better therapeutic outcomes and patient compliance.