CYCLODEXTRIN-BASED SOLUBILITY ENHANCEMENT OF POORLY WATER-SOLUBLE DRUG INDOMETHACIN

Abstract

Indomethacin, a non-steroidal antiinflammatory drug (NSAID), suffers from low aqueous solubility, limiting its oral bioavailability and therapeutic effectiveness. Cyclodextrins, particularly hydroxypropyl-βcyclodextrin (HP-β-CD), are widely employed to enhance solubility and dissolution of poorly water-soluble drugs through inclusion complexation. This study focuses on the preparation and evaluation of indomethacin– HP-β-CD inclusion complexes using coprecipitation and kneading methods. The complexes were characterized using Fouriertransform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) to confirm complex formation. Solubility and in vitro dissolution studies demonstrated a significant increase in the aqueous solubility and dissolution rate of indomethacin when complexed with HP-β-CD. These results indicate that cyclodextrin-based inclusion complexes effectively enhance the physicochemical properties of indomethacin, providing a promising strategy to improve its oral bioavailability.