EXTRACTION OF EGGSHELL MEMBRANE AND ITS APPLICATION AS A NATURAL DIALYSIS MEMBRANE FOR EX-VIVO DRUG PERMEATION STUDIES

Abstract

Eggshell membrane (ESM) is a natural, protein-rich biomaterial that has gained increasing attention in pharmaceutical research due to its biocompatibility, selective permeability, and adsorption capabilities [1–5]. ESM serves as a versatile and cost-effective ex vivo membrane system, offering several advantages over conventional synthetic dialysis membranes [14,15]. Its unique fibrous architecture and biochemical composition allow realistic assessment of drug permeation, formulation– protein interactions, and controlled-release behavior. These properties make ESM an emerging platform for developing natural biomaterial-based wound dressings, topical delivery systems and therapeutic matrices. This research paper aim on the recent advancements in ESM separation techniques and applications in the Pharmaceutical Industry for improving the separation, dissolution, and efficient development and utilization of avian eggshell membranes.